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Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
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一家老牌抗体原产企业,专注于研发多种指标单克隆抗体和多克隆抗体,产品涉及细胞通路、细胞生物学、神经生物学、表观遗传学、癌症等多个领域;标签抗体和GFP抗体种类丰富;同时专注各类荧光二抗和Trueblot特色产品的开发。