产品描述说明： TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells. 品牌简介： 一家老牌抗体原产企业，专注于研发多种指标单克隆抗体和多克隆抗体，产品涉及细胞通路、细胞生物学、神经生物学、表观遗传学、癌症等多个领域；标签抗体和GFP抗体种类丰富；同时专注各类荧光二抗和Trueblot特色产品的开发。