产品描述说明：Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity; it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3T9]. 品牌简介： 世界排名前十的抗体生产商，以优质的兔多克隆抗体闻名，所有抗体都经过一系列实验技术的检验，如：ELISA，WB，IP，ChIP，PLA（邻近连接技术），IHC和ICC等；不断生产出新的抗体，产品不仅针对新兴领域的热门蛋白，也包括一直以来缺少高质量检测抗体的经典蛋白。目前已拥有针对2300种目标蛋白而生产出来的近7000种一抗，同时也可提供针对来自27个种属的免疫球蛋白的二抗；抗体定制方面有40年的经验。