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WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].
体外研究
(In Vitro)
WRW4 抑制 Abeta42 肽诱导的中性粒细胞超氧化物生成和趋化性迁移，还完全抑制 Abeta42 肽在人巨噬细胞中的内化。WRW4 通过 WKYMVm 特异性阻断 FPRL1 下游的 ERK 磷酸化[1]。
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1104.27
Formula
C61H65N15O6
CAS 号
878557-55-2
性状
固体
颜色
White to off-white
Sequence Shortening
WRWWWW-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years
-20°C 1 year
产品详情见链接：https://www.medchemexpress.cn/wrw4.html
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].
体外研究
(In Vitro)
WRW4 抑制 Abeta42 肽诱导的中性粒细胞超氧化物生成和趋化性迁移，还完全抑制 Abeta42 肽在人巨噬细胞中的内化。WRW4 通过 WKYMVm 特异性阻断 FPRL1 下游的 ERK 磷酸化[1]。
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1104.27
Formula
C61H65N15O6
CAS 号
878557-55-2
性状
固体
颜色
White to off-white
Sequence Shortening
WRWWWW-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years
-20°C 1 year
产品详情见链接：https://www.medchemexpress.cn/wrw4.html