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Aspulvinone O
  • 商城价格 登录后可查看价格
  • 货号 KCM15737-1
  • 品牌 KKL MED/凯库勒 ( 经销商 )
  • CAS号 914071-54-8
  • 规格/包装 1mg
  • 单位 瓶
  • 储存条件 见包装
  • 现货状态 现货
  • 数量

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Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC = 11.6 µM). Aspulvinone O inhibits aspartate transaminase 1 (GOT1; K = 3.32 µM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (ICs = 20.54-26.8 µM). It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.
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