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Myrothecine A is a trichothecene mycotoxin that has been found in M. roridum and has anticancer activities. It inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (ICs = 95, 70, 60, and 25 µM, respectively). Myrothecine A (50 µM) induces G cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells.