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AR-42 is a novel HDAC inhibitor (IC50 value of 16 nM) with potent anticancer effects in pancreatic cancer cells at submicromolar concentrations by inducing cell cycle arrest, stimulating apoptosis, and regulating expression of several miRNAs. Also demonstrated anticancer activity in many other cancers, including acute myeloid leukemia, multiple myeloma, prostate cancer, ovarian cancer, human glioma cells, and bladder cancer.