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胎牛血清 移液枪头 PEI DMEM eppendorf
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JTP 1048196
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  • 货号 KA1497-1
  • 品牌 KKL MED/凯库勒 ( 经销商 )
  • CAS号 55377-56-5
  • 规格/包装 10mg
  • 单位 瓶
  • 储存条件 见包装
  • 现货状态 现货
  • 数量

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JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels.
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