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Very potent blocker for the human excitatory amino acid transporters (IC50 values 22 nM, 17 nM, and 300 nM, for EAAT1, EAAT2, and EAAT3, respectively). TFB-BOA is more potent at inhibiting EAAT1 and EAAT2 compared with L-TBOA, and induced spontaneous epileptiform discharges and convulsive behaviors in mice. An important tool for elucidation of the physiological roles of EAATs and their contribution to the etiology of neuronal disorders.