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PROteolysis TArgeting Chimeras (PROTACs) have emerged as novel therapeutics to target the undruggable proteome. PROTACs are heterobifunctional small molecules that both simultaneously bind to a target protein and a ubiquitin (Ub) E3 ligase. This subsequently leads to ubiquitination and degradation of the target protein.
LifeSensors has developed a high-throughput plate-based method to directly monitor PROTAC-mediated ubiquitination and degradation of target proteins. This method is rapid, efficient, and quantitative and works with endogenous proteins and cell lines. There is no need for stable cell line production or tagging your target protein and creating artifacts. In other words, you can create native conditions to gather the most accurate data possible.
PROteolysis TArgeting Chimeras (PROTACs) have emerged as novel therapeutics to target the undruggable proteome. PROTACs are heterobifunctional small molecules that both simultaneously bind to a target protein and a ubiquitin (Ub) E3 ligase. This subsequently leads to ubiquitination and degradation of the target protein.
LifeSensors has developed a high-throughput plate-based method to directly monitor PROTAC-mediated ubiquitination and degradation of target proteins. This method is rapid, efficient, and quantitative and works with endogenous proteins and cell lines. There is no need for stable cell line production or tagging your target protein and creating artifacts. In other words, you can create native conditions to gather the most accurate data possible.