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经过测试的应用
Positive WB detected in A549 cells, HEK-293T cells, Raji cells, U-251 cells, mouse brain tissue, rat brain tissue
Positive IF detected in U2OS cells
推荐稀释比
APPLICATION DILUTION
Western Blot (WB) WB : 1:500-1:3000
Immunofluorescence (IF) IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.
产品信息
30022-1-AP targets HIP14; ZDHHC17 in WB, IF, ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications IF/ICC, WB, ELISA
Tested Reactivity Human, Mouse, Rat
Immunogen HIP14; ZDHHC17 fusion protein Ag32654 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name zinc finger, DHHC-type containing 17
Synonyms DHHC 17, HIP 14, HIP 3, HIP14, HIP3, HSPC294, Huntingtin yeast partner H, HYPH, KIAA0946, Palmitoyltransferase ZDHHC17, ZDHHC17
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 70 kDa
GenBank Accession Number BC050324
Gene Symbol ZDHHC17
Gene ID (NCBI) 23390
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
UNIPROT ID Q8IUH5
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
背景介绍
ZDHHC17 is a neuronal palmitoyl transferase. Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. ZDHHC17 gene encodes palmitoyl transferase huntingtin interacting protein (HIP14) which regulates palmitoylation and distribution of hungtingtin. The latter is implicated in the formation of inclusion bodies and enhanced neuronal toxicity. HIP14 was also shown to control neurotransmitter release.
Positive WB detected in A549 cells, HEK-293T cells, Raji cells, U-251 cells, mouse brain tissue, rat brain tissue
Positive IF detected in U2OS cells
推荐稀释比
APPLICATION DILUTION
Western Blot (WB) WB : 1:500-1:3000
Immunofluorescence (IF) IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.
产品信息
30022-1-AP targets HIP14; ZDHHC17 in WB, IF, ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications IF/ICC, WB, ELISA
Tested Reactivity Human, Mouse, Rat
Immunogen HIP14; ZDHHC17 fusion protein Ag32654 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name zinc finger, DHHC-type containing 17
Synonyms DHHC 17, HIP 14, HIP 3, HIP14, HIP3, HSPC294, Huntingtin yeast partner H, HYPH, KIAA0946, Palmitoyltransferase ZDHHC17, ZDHHC17
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 70 kDa
GenBank Accession Number BC050324
Gene Symbol ZDHHC17
Gene ID (NCBI) 23390
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
UNIPROT ID Q8IUH5
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
背景介绍
ZDHHC17 is a neuronal palmitoyl transferase. Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. ZDHHC17 gene encodes palmitoyl transferase huntingtin interacting protein (HIP14) which regulates palmitoylation and distribution of hungtingtin. The latter is implicated in the formation of inclusion bodies and enhanced neuronal toxicity. HIP14 was also shown to control neurotransmitter release.
