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Monoclonal antibody OX-42 recognises most macrophages (including resident peritoneal and activated macrophages), Kupffer cells, but only about 35% of alveolar macrophages. It also labels dendritic cells extensively, and granulocytes and cells with the morphology of microglia in the brain. OX-42 is probably the rat equivalent of the human CR3 complement receptor for iC3b. In combination with OX-41 it facilitates a more distinct phenotyping of resident macrophages.
