Recombinant Lamin A produced in E。Coli is a single， non-glycosylated polypeptide chain containing 645 amino acids and having a molecular mass of 70 kDa。 Lamin-A is a major component of the nuclear lamina， a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene （LMNA）。 Lamin-A is synthesized as Prelamin A， a longer precursor that in vivo goes through a serial post-translational modifications that lead to mature Lamin A。 Diverse mutations in the Lamin A/C gene are associated with different diseases that are collectively called laminophaties， including Emery-Dreifuss muscular dystrophy， familiar partial lipodystrophy， limb girdle muscular dystrophy， dilated cardiomyopathy， Charcot-Marie-Tooth disease， and Hutchinson-Gilford progeria syndrome。
郑重提醒：艾美捷科技作为全球著名细胞因子蛋白及相关抗体生产和研发品牌ProSpec中国区域代理，我们提供基于独有的细菌和哺乳动物表达和蛋白折叠技术所生产的细胞因子，生长因子，激素，信号蛋白，病毒抗原等近5000种重组蛋白和600多种抗体。我们也将一如既往更加努力为国内用户提供快捷、方便的高质量产品，同时更为您售前售后全面技术支持。欢迎垂询：400-6800-868，www.amyjet.com