c-Myc is a multifunctional， nuclear phosphoprotein that plays a role in cell cycle progression， apoptosis and cellular transformation。 It functions as a transcription factor that regulates transcription of specific target genes。 Mutations， overexpression， rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors， leukemias and lymphomas， including Burkitt lymphoma。 There is evidence to show that alternative translation initiations from an upstream， in-frame non-AUG （CUG） and a downstream AUG start site result in the production of two isoforms with distinct N-termini。 The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas， suggesting its importance in the normal function of this gene。
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