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2AB labelled sialylated core 1 O glycan, C1S(3)1
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  • 货号 CAB-C1S(3)1-01
  • 品牌 Ludger ( 经销商 )
  • CAS号
  • 规格/包装 100 pmol
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  • 现货状态 询货

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Core And Sialylated O-Glycan Standards O-glycosylation is a common covalent modification of serine and threonine residues of mammalian glycoproteins. The most common type of O-glycosylation found on secreted mammalian glycoproteins and mucins (proteins conjugated to carbohydrate) is from the addition of N-acytylgalactosamine (GalNac) to serine or threonine residues. The Core 1 structure is generated by the addition of galactose b1-3 to this GalNAc. The Core 2 structure is generated by the further addition of N-acetyl-glucosamine b1-6 to the N-acetyl-galactosamine on the Core 1 structure. In total eight different core structures have been identified and all of these can be further elongated by the addition of a number of monosaccharides including sialic acids. These O-glycans are present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel) and human Factor VIII (FVIII). Core 1 and Core 2 O-glycans are also present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel), human Factor VIII (FVIII), Factor IX and insulin glargine. Six 2-AB labelled Core 1 and Core 2 O glycan standards are now available. The standards typically have a purity of > 93% as assessed by HILIC-HPLC and can be used as internal references or system suitability standards for peak assignment during HPLC or UPLC analysis.
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