编号：C49738-100ul

产品名称：Nuclear Matrix Protein p84 Conjugated Antibody

种属反应性：Hu,,Ms,,Rt

来源种属：Rabbit

克隆性：Monoclonal

规格：100ul

标记物:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750

应用详情：Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

特异性：

其他名称：hTREX84 antibody
Death domain containing protein p84N5 antibody
HPR 1 antibody
HPR1 antibody
hTREX84 antibody
Nuclear matrix protein p84 antibody
P84 antibody
p84N5 antibody
Tho 1 antibody
THO complex 1 antibody
THO complex subunit 1 antibody
Tho1 antibody
THOC 1 antibody
Thoc1 antibody
THOC1_HUMAN antibody


计算分子量：76 kDa

免疫原描述：Recombinant protein

标记：Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750

激发/发射波长：AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

配方：0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存：Store at 4˚C in dark for 6 months

背景：THOC1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THOC1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THOC1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THOC1 in cancer cell lines results in reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THOC1 expression and therefore THOC1 may be a good target for cancer therapy.

产地：SAB 美国

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