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FOXO1A Conjugated Antibody
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  • 货号 FOXO1A Conjugated Antibod
  • 品牌 Signalway Antibody LLC(SAB) ( 一级代理 )
  • CAS号
  • 规格/包装 100ul 来源:兔子单克隆 AF标记抗
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编号:C48816-100ul

产品名称:FOXO1A Conjugated Antibody

种属反应性:Hu,,Ms,,Rt,,zebrafish

来源种属:Rabbit

克隆性:Monoclonal

规格:100ul

标记物:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750

应用详情:Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

特异性:

其他名称:FKH 1 antibody
FKH1 antibody
FKHR antibody
Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody
Forkhead box O1 antibody
Forkhead box protein O1 antibody
Forkhead box protein O1A antibody
Forkhead in rhabdomyosarcoma antibody
Forkhead, Drosophila, homolog of, in rhabdomyosarcoma antibody
FoxO transcription factor antibody
foxo1 antibody
FOXO1_HUMAN antibody
FOXO1A antibody
OTTHUMP00000018301 antibody


计算分子量:80 kDa

免疫原描述:recombinant protein

标记:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750

激发/发射波长:AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

配方:0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存:Store at 4˚C in dark for 6 months

背景:FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxy-terminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.

产地:SAB 美国

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