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编号：C42577-100ul
产品名称：Advanced glycosylation end product-specific receptor Polyclonal Conjugated Antibody
种属反应性：Hu
来源种属：Rabbit
克隆性：Polyclonal
规格：100ul
标记物:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750
应用详情：Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000
特异性：The antibody detects endogenous level of total Advanced glycosylation end product-specific receptor polyclonal antibody.
其他名称：Receptor for advanced glycosylation end products,AGER, RAGE
计算分子量：44
免疫原描述：Recombinant human Advanced glycosylation end product-specific receptor protein
标记：Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750
激发/发射波长：AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
配方：0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
保存：Store at 4˚C in dark for 6 months
背景：Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
产地：SAB 美国
//品牌：SAB Signalway Antibody/////更多产品欢迎查询我们官网：www.salmart.cn，销售人员QQ：439095771 QQ：996676869 电话：0755-33160345，13006636686
产品名称：Advanced glycosylation end product-specific receptor Polyclonal Conjugated Antibody
种属反应性：Hu
来源种属：Rabbit
克隆性：Polyclonal
规格：100ul
标记物:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750
应用详情：Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000
特异性：The antibody detects endogenous level of total Advanced glycosylation end product-specific receptor polyclonal antibody.
其他名称：Receptor for advanced glycosylation end products,AGER, RAGE
计算分子量：44
免疫原描述：Recombinant human Advanced glycosylation end product-specific receptor protein
标记：Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750
激发/发射波长：AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
配方：0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
保存：Store at 4˚C in dark for 6 months
背景：Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
产地：SAB 美国
//品牌：SAB Signalway Antibody/////更多产品欢迎查询我们官网：www.salmart.cn，销售人员QQ：439095771 QQ：996676869 电话：0755-33160345，13006636686
