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MyD88 Conjugated Antibody
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  • 货号 MyD88 Conjugated Antibody
  • 品牌 Signalway Antibody LLC(SAB) ( 一级代理 )
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  • 规格/包装 100ul 来源:兔子多克隆 AF标记抗
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编号:C32107-100ul//产品名称:MyD88 Conjugated Antibody//种属反应性:Hu,Ms,Rt//来源种属:Rabbit//克隆性:Polyclonal//规格:100ul//标记物:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750//应用详情:Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000//特异性:The antibody detects endogenous level of total MyD88 protein.//其他名称:MYD88D//计算分子量:33//免疫原描述:Recombinant protein of human MyD88.//标记:Biotin,AF350,AF405,AF488,AF555,AF594,AF647,AF680,AF750//激发/发射波长:AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm //配方:0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide//保存:Store at 4˚C in dark for 6 months //背景:Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasm. MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages (4-6). It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling (7). The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-κB (8,9).//产地:SAB 美国//品牌:SAB Signalway Antibody/////更多产品欢迎查询我们官网:www.salmart.cn,销售人员QQ:439095771 QQ:996676869 电话:0755-33160345,13006636686
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