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JPM-OEt
产品活性:JPM-OEt 是一种广谱的半胱氨酸组织蛋白酶 (cysteine cathepsin) 抑制剂。JPM-OEt 在活性位点共价结合,并且不可逆地抑制半胱氨酸组织蛋白酶家族。具有抗肿瘤活性。
产品来源: https://www.medchemexpress.cn/jpm-oet.html
研究领域:Metabolic Enzyme/Protease
作用靶点:作用靶点:Cathepsin
In Vivo: JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly.
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis.
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment.
相关产品:Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Leupeptin hemisulfate | Aloxistatin | PMSF | E-64 | N-Ethylmaleimide | CA-074 methyl ester | CA-074 | Papain | Calpeptin | LY 3000328 | SID 26681509 | S130 | E 64c | LV-320 | Z-WEHD-FMK | LHVS | NSC 185058 | Z-LVG-CHN2 | Cysteine Protease inhibitor hydrochloride | ONO-5334 | 3-Epiursolic Acid | 2-Cyanopyrimidine | Asperphenamate | ALLM | Aurantiamide acetate | Cathepsin D and E FRET Substrate | K777
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