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Polygalasaponin F异牡荆苷
  • 商城价格 登录后可查看价格
  • 货号 T3826-25mg
  • 品牌 TargetMol ( 经销商 )
  • CAS号 882664-74-6
  • 规格/包装 25mg
  • 单位
  • 储存条件
  • 现货状态 三个工作日

  • 数量

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Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.
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