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Syk Inhibitor II (hydrochloride)
  • 商城价格 登录后可查看价格
  • 货号 T4391-2mg
  • 品牌 TargetMol ( 经销商 )
  • CAS号 227449-73-2
  • 规格/包装 2mg
  • 单位 个
  • 储存条件
  • 现货状态 三个工作日
  • 数量

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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
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