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I-CBP112 hydrochloride
  • 商城价格 登录后可查看价格
  • 货号 T4247-2mg
  • 品牌 TargetMol ( 经销商 )
  • CAS号 2147701-33-3
  • 规格/包装 2mg
  • 单位 个
  • 储存条件
  • 现货状态 三个工作日
  • 数量

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I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
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