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KCNIP3 / Dream / Calsenilin Antibody (aa29-78)
  • 商城价格 登录后可查看价格
  • 货号 LBP78902
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 50 μl
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LBP78902

规格：

50 μl

产品官网链接：

产品分类：

多克隆抗体

研究领域：

产品概述：

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

来源：

Rabbit

靶点/蛋白质：

Calsenilin/KCNIP3 antibody detects endogenous levels of total Calsenilin/KCNIP3 protein.

特异性：

Human, Mouse

存储温度：

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液：

应用：

ELISA (1:20000), IF (1:100-1:500), IHC-P (10 μg/ml), WB (1:500-1:1000) ,

参考文献：

Buxbaum J.D.,et al.Nat. Med. 4:1177-1181(1998). Carrion A.M.,et al.Nature 398:80-84(1999). An W.F.,et al.Nature 403:553-556(2000). Pruunsild P.,et al.Genomics 86:581-593(2005). Isbrandt D.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.

详情介绍：

Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. Cellular_Location Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. Tissue_Location Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease

别名：

Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3, KCNIP3, CSEN, DREAM, KCHIP3

说明书：

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