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品牌: | Leading Biology | 货号: | LBP72800 |
规格: | 100 μl | 产品官网链接: | |
产品分类: | 多克隆抗体 | 研究领域: | |
产品概述: | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. | 来源: | Rabbit |
靶点/蛋白质: | 特异性: | Human | |
存储温度: | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | 存储溶液: | 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50% |
应用: | WB~~ 1:1000 | 参考文献: | Adachi M.,et al.Biochem. Biophys. Res. Commun. 180:1265-1272(1991). Cyr C.,et al.Biochem. Biophys. Res. Commun. 181:184-190(1991). Hosoda K.,et al.FEBS Lett. 287:23-26(1991). Arai H.,et al.Jpn. Circ. J. 56:1303-1307(1992). Elshourbagy N.A.,et al.J. Biol. Chem. 268:3873-3879(1993). |
详情介绍: | Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Cellular_Location Cell membrane; Multi-pass membrane protein. Tissue_Location Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. | ||
别名: | Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA | 说明书: |