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Granzyme A Antibody
  • 商城价格 登录后可查看价格
  • 货号 LBP67140
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
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品牌：

Leading Biology

货号：

LBP67140

规格：

100 μg

产品官网链接：

产品分类：

多克隆抗体

研究领域：

产品概述：

Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells. Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates

来源：

Rabbit

靶点/蛋白质：

Granzyme A

特异性：

Human, Mouse, Rat

存储温度：

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液：

应用：

参考文献：

详情介绍：

Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cellular_Location Isoform alpha: Secreted. Cytoplasmic granule

别名：

CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF

说明书：

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