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品牌: | Leading Biology | 货号: | LBP63172 |
规格: | 50 μg | 产品官网链接: | |
产品分类: | 多克隆抗体 | 研究领域: | |
产品概述: | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. | 来源: | Rabbit |
靶点/蛋白质: | Human RARB. BLAST analysis of the peptide immunogen showed no homology with other human proteins. | 特异性: | Human, Monkey, Pig, Horse |
存储温度: | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | 存储溶液: | |
应用: | IHC-P (10 μg/ml) | 参考文献: | Benbrook D.,et al.Nature 333:669-672(1988). de The H.,et al.Nature 330:667-670(1987). Sommer K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:8651-8656(1999). Shen S.,et al.DNA Seq. 2:111-119(1991). Houle B.,et al.Cancer Res. 54:365-369(1994). |
详情介绍: | Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Cellular_Location Isoform Beta-1: Nucleus. Isoform Beta-4: Cytoplasm. | ||
别名: | Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, RARB, HAP, NR1B2 | 说明书: |