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品牌: | Leading Biology | 货号: | LBP60671 |
规格: | 100 μg | 产品官网链接: | |
产品分类: | 多克隆抗体 | 研究领域: | |
产品概述: | c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins, and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activate c-Jun. | 来源: | Rabbit |
靶点/蛋白质: | c-Jun | 特异性: | Human, Mouse, Rat |
存储温度: | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | 存储溶液: | |
应用: | 参考文献: | ||
详情介绍: | Function Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Cellular_Location Nucleus. | ||
别名: | JUN , AP1 , p39 , c-Jun | 说明书: |