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品牌： | Leading Biology | 货号： | LM17526 |
规格： | 100 μg | 产品官网链接： | |
产品分类： | 单克隆抗体 | 研究领域： | |
产品概述： | This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene. | 来源： | mouse |
靶点/蛋白质： | PEPD (AAH15027, 1 a.a. ~ 493 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | 特异性： | Human |
存储温度： | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | 存储溶液： | Clear, colorless solution in phosphate buffered saline, pH 7.2. |
应用： | WB~~1:500~1000 | 参考文献： | Dilatation of the ascending aorta is associated with low serum prolidase activity. Akcakoyun M, et al. Tohoku J Exp Med, 2010. PMID 20383038. Prolidase activity and oxidative status in patients with thalassemia major. Cakmak A, et al. J Clin Lab Anal, 2010. PMID 20087956. Serum prolidase activity and oxidative status in patients with stage I endometrial cancer. Arioz DT, et al. Int J Gynecol Cancer, 2009 Oct. PMID 19823062. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Takeuchi F, et al. Diabetes, 2009 Jul. PMID 19401414. Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency. Uramatsu S, et al. Amino Acids, 2009 Sep. PMID 19263194. |
详情介绍： | |||
别名： | Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase, PEPD, PRD | 说明书： | |