搜索

购物车()
胎牛血清 移液枪头 PEI DMEM eppendorf
首页> 生物试剂> 免疫检测> 抗体


PDZK1 Antibody (clone AT1A2)
  • 商城价格 登录后可查看价格
  • 货号 LM17524
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 50 μl
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
  • 数量

    - +

    成功收藏产品
  • 立即购买
登录后可见商家信息
热门推荐
商家描述 产品评价(0)

品牌：

Leading Biology

货号：

LM17524

规格：

50 μl

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

来源：

Mouse

靶点/蛋白质：

Human PDZK1

特异性：

Human

存储温度：

存储溶液：

应用：

IHC-P (10 μg/ml), WB (1:1000),

参考文献：

Kocher O.,et al.Lab. Invest. 78:117-125(1998). Ota T.,et al.Nat. Genet. 36:40-45(2004). Gregory S.G.,et al.Nature 441:315-321(2006). Kocher O.,et al.Lab. Invest. 79:1161-1170(1999). Wang S.,et al.Cell 103:169-179(2000).

详情介绍：

Function A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Cellular_Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity). Tissue_Location Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.

别名：

PDZK1, CAP70, CLAMP, NHERF-3, PDZD1, PDZ domain containing 1, NaPi-Cap1, NHERF3

说明书：

返回顶部