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PDX1 Antibody
  • 商城价格 登录后可查看价格
  • 货号 LM17521
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μl
  • 单位
  • 储存条件 见详情介绍
  • 现货状态

  • 数量

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品牌:

Leading Biology

货号:

LM17521

规格:

100 μl

产品官网链接:

产品分类:

单克隆抗体

研究领域:

产品概述:

来源:

Mouse

靶点/蛋白质:

特异性:

Human

存储温度:

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液:

应用:

E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400

参考文献:

J Biol Chem. 2009 Dec 25;284(52):36482-90. Pancreatology. 2009;9(1-2):116-26.

详情介绍:

Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Cellular_Location Nucleus. Cytoplasm, cytosol. Tissue_Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells)

别名:

Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1

说明书:

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