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PDK4 Antibody
  • 商城价格 登录后可查看价格
  • 货号 LM17519
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 400 μl
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM17519

规格：

400 μl

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

This gene is a member of the PDK/BCKDK protein kinasefamily and encodes a mitochondrial protein with a histidine kinasedomain. This protein is located in the matrix of the mitrochondriaand inhibits the pyruvate dehydrogenase complex by phosphorylatingone of its subunits, thereby contributing to the regulation ofglucose metabolism. Expression of this gene is regulated byglucocorticoids, retinoic acid and insulin.

来源：

Mouse

靶点/蛋白质：

Purified His-tagged PDK4 protein(Fragment) was used to produced this monoclonal antibody.

特异性：

Human

存储温度：

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液：

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

应用：

WB~~1:100

参考文献：

Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008) Wynn, R.M., et al. J. Biol. Chem. 283(37):25305-25315(2008) Cadoudal, T., et al. Diabetes 57(9):2272-2279(2008) Tsintzas, K., et al. J. Clin. Endocrinol. Metab. 92(10):3967-3972(2007) Degenhardt, T., et al. J. Mol. Biol. 372(2):341-355(2007)

详情介绍：

Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. Cellular_Location Mitochondrion matrix. Tissue_Location Ubiquitous; highest levels of expression in heart and skeletal muscle.

别名：

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4, PDK4, PDHK4

说明书：

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