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PDK2 Antibody
  • 商城价格 登录后可查看价格
  • 货号 LM17512
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 400 μl
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM17512

规格：

400 μl

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

来源：

Mouse

靶点/蛋白质：

This PDK2 monoclonal antibody is generated from mouse immunized with PDK2 recombinant protein.

特异性：

Human, Mouse

存储温度：

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液：

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

应用：

WB~~1:100~500 IHC-P~~1:25

参考文献：

Li, J., et al. J. Biol. Chem. 284(49):34458-34467(2009) Fencl, F., et al. Pediatr. Nephrol. 24(5):983-989(2009) Sun, W., et al. Clin. Cancer Res. 15(2):476-484(2009) Hiromasa, Y., et al. Biochemistry 47(8):2312-2324(2008) Hiromasa, Y., et al. Biochemistry 47(8):2298-2311(2008)

详情介绍：

Function Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Cellular_Location Mitochondrion matrix. Tissue_Location Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung

别名：

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2

说明书：

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