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PCSK1 Antibody (monoclonal) (M02)
  • 商城价格 登录后可查看价格
  • 货号 LM17503
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
  • 数量

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品牌：

Leading Biology

货号：

LM17503

规格：

100 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

来源：

Mouse

靶点/蛋白质：

PCSK1 (NP_000430, 652 a.a. ~ 753 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

特异性：

Human, Mouse, Rat

存储温度：

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

存储溶液：

Clear, colorless solution in phosphate buffered saline, pH 7.2.

应用：

WB~~1:500~1000

参考文献：

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion. Heni M, et al. BMC Med Genet, 2010 Jun 9. PMID 20534142.Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. Qi Q, et al. PLoS One, 2010 May 17. PMID 20498726.Solution structure of proinsulin: connecting domain flexibility and prohormone processing. Yang Y, et al. J Biol Chem, 2010 Mar 12. PMID 20106974.

详情介绍：

别名：

Neuroendocrine convertase 1, NEC 1, Prohormone convertase 1, Proprotein convertase 1, PC1, PCSK1, NEC1

说明书：

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