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PAWR Antibody (clone 3G9H7,4H12E9)
  • 商城价格 登录后可查看价格
  • 货号 LM17498
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 50 μl
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM17498

规格：

50 μl

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

来源：

Mouse

靶点/蛋白质：

Human PAWR

特异性：

Human

存储温度：

存储溶液：

应用：

ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)

参考文献：

Johnstone R.W.,et al.Mol. Cell. Biol. 16:6945-6956(1996). Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Hsu S.-C.,et al.Gene 295:109-116(2002). Chakraborty M.,et al.Cancer Res. 61:7255-7263(2001). Chang S.,et al.FEBS Lett. 510:57-61(2002).

详情介绍：

Function Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Cellular_Location Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. Tissue_Location Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers

别名：

PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4, PAWR, PAR4

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