搜索

购物车()
胎牛血清 移液枪头 PEI DMEM eppendorf
首页> 生物试剂> 免疫检测> 抗体


PARP1 Antibody (monoclonal) (M01)
  • 商城价格 登录后可查看价格
  • 货号 LM17497
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
  • 数量

    - +

    成功收藏产品
  • 立即购买
登录后可见商家信息
热门推荐
商家描述 产品评价(0)

品牌：

Leading Biology

货号：

LM17497

规格：

100 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

来源：

mouse

靶点/蛋白质：

PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

特异性：

Human

存储温度：

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

存储溶液：

Clear, colorless solution in phosphate buffered saline, pH 7.2.

应用：

WB~~1:500~1000

参考文献：

1.The ADP-ribosyltransferase PARP10/ARTD10 interacts with Proliferating Cell Nuclear Antigen (PCNA) and is required for DNA damage tolerance.Nicolae CM, Aho ER, Vlahos AH, Choe KN, De S, Karras GI, Moldovan GLJ Biol Chem. 2014 May 9;289(19):13627-37. doi: 10.1074/jbc.M114.556340. Epub 2014 Apr 2.2.Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double strand breaks.Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJCancer Res. 2013 May 21.3.DDB2 promotes chromatin decondensation at UV-induced DNA damage.Luijsterburg MS, Lindh M, Acs K, Vrouwe MG, Pines A, van Attikum H, Mullenders LH, Dantuma NP.J Cell Biol. 2012 Apr 9. [Epub ahead of print]4.PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N, Vermeulen W, Vrieling H, Mullenders L.J Cell Biol. 2012 Oct 8. [Epub ahead of print]5.The Metastasis Efficiency Modifier Ribosomal RNA Processing 1 Homolog B (RRP1B) Is a Chromatin-associated Factor.Crawford NP, Yang H, Mattaini KR, Hunter KW.J Biol Chem. 2009 Oct 16;284(42):28660-73. Epub 2009 Aug 26.

详情介绍：

别名：

Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL

说明书：

返回顶部