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PARP Antibody (Clone 10H)
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  • 货号 LM17490
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM17490

规格：

100 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.

来源：

Mouse

靶点/蛋白质：

PARP

特异性：

All Species

存储温度：

存储溶液：

应用：

参考文献：

详情介绍：

Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Cellular_Location Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage

别名：

PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1

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