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品牌: | Leading Biology | 货号: | LM17486 |
规格: | 100 μg | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. | 来源: | mouse |
靶点/蛋白质: | PAFAH1B3 (AAH03016, 1 a.a. ~ 231 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | 特异性: | Human, Rat |
存储温度: | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | 存储溶液: | Clear, colorless solution in phosphate buffered saline, pH 7.2. |
应用: | WB~~1:500~1000 | 参考文献: | 1.Loss of PAFAH1B2 Reduces Amyloid-?] Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments.Page RM, Munch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C.J Neurosci. 2012 Dec 12;32(50):18204-18214. |
详情介绍: | |||
别名: | Platelet-activating factor acetylhydrolase IB subunit gamma, PAF acetylhydrolase 29 kDa subunit, PAF-AH 29 kDa subunit, PAF-AH subunit gamma, PAFAH subunit gamma, PAFAH1B3, PAFAHG | 说明书: |