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p63α Antibody
  • 商城价格 登录后可查看价格
  • 货号 LM17482
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μl
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
  • 数量

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品牌：

Leading Biology

货号：

LM17482

规格：

100 μl

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

来源：

Mouse

靶点/蛋白质：

特异性：

Human, Mouse, Rat, Monkey

存储温度：

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

存储溶液：

应用：

E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000

参考文献：

1. Cancer Res. 2008 Jul 1;68(13):5122-31. 2. Eur J Med Genet. 2008 Sep-Oct;51(5):497-500.

详情介绍：

Function Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Cellular_Location Nucleus Tissue_Location Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues

别名：

Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L

说明书：

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