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品牌: | Leading Biology | 货号: | LM17479 |
规格: | 100 μg | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene. | 来源: | mouse |
靶点/蛋白质: | OPRL1 (AAH38433, 110 a.a. ~ 212 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | 特异性: | Human |
存储温度: | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | 存储溶液: | Clear, colorless solution in phosphate buffered saline, pH 7.2. |
应用: | 参考文献: | A Pilot Study of Gene/Gene and Gene/Environment Interactions in Alzheimer Disease. Ghebranious N, et al. Clin Med Res, 2010 Aug 3. PMID 20682755.Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Briant JA, et al. Psychiatr Genet, 2010 Apr. PMID 20032820.Genetical genomic determinants of alcohol consumption in rats and humans. Tabakoff B, et al. BMC Biol, 2009 Oct 27. PMID 19874574.Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics. Kuzmin A, et al. Brain Res, 2009 Dec 11. PMID 19501074.A common variant in DRD3 receptor is associated with autism spectrum disorder. de Krom M, et al. Biol Psychiatry, 2009 Apr 1. PMID 19058789. | |
详情介绍: | |||
别名: | Nociceptin receptor, Kappa-type 3 opioid receptor, KOR-3, Orphanin FQ receptor, OPRL1, OOR, ORL1 | 说明书: |