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品牌: | Leading Biology | 货号: | LM17475 |
规格: | 100 μl | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | 来源: | Mouse | |
靶点/蛋白质: | 特异性: | Human | |
存储温度: | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | 存储溶液: | |
应用: | WB~~1/500 - 1/2000 | 参考文献: | 1. J Biol Chem. 2008 Dec 19;283(51):35825-33. 2. Dev Genes Evol. 2008 Oct;218(10):561-6. 3. Stem Cells. 2008 Sep;26(9):2419-24. |
详情介绍: | Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Cellular_Location Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern Tissue_Location Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. | ||
别名: | POU domain, class 5, transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3 | 说明书: |