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NR1H2 Antibody (monoclonal) (M04)
  • 商城价格 登录后可查看价格
  • 货号 LM17454
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
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  • 数量

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品牌：

Leading Biology

货号：

LM17454

规格：

100 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

来源：

mouse

靶点/蛋白质：

NR1H2 (AAH07790.1, 1 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

特异性：

Human, Rat

存储温度：

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

存储溶液：

Clear, colorless solution in phosphate buffered saline, pH 7.2.

应用：

WB~~1:500~1000

参考文献：

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration. Walcher D, et al. Basic Res Cardiol, 2010 Jul. PMID 20364260.Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. Christoffolete MA, et al. J Endocrinol, 2010 May. PMID 20176747.GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Venteclef N, et al. Genes Dev, 2010 Feb 15. PMID 20159957.Integrative predictive model of coronary artery calcification in atherosclerosis. McGeachie M, et al. Circulation, 2009 Dec 15. PMID 19948975.

详情介绍：

别名：

Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, NR1H2, LXRB, NER, UNR

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