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NEUROD1 Antibody (clone 3H8)
  • 商城价格 登录后可查看价格
  • 货号 LM17422
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 50 μg
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
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品牌：

Leading Biology

货号：

LM17422

规格：

50 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

来源：

Mouse

靶点/蛋白质：

Human NeuroD1

特异性：

Human

存储温度：

存储溶液：

应用：

IF (10 μg/ml), IHC-P (5 μg/ml),

参考文献：

Tamimi R.,et al.Genomics 34:418-421(1996). Yokoyama M.,et al.Brain Res. Mol. Brain Res. 42:135-139(1996). Furuta H.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. Miyachi T.,et al.Brain Res. Mol. Brain Res. 69:223-231(1999). Noma T.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.

详情介绍：

Function Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). Cellular_Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14752053}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus.

别名：

Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3, NEUROD1, BHLHA3, NEUROD

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