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品牌: | Leading Biology | 货号: | LM17417 |
规格: | 100 μl | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | 来源: | Mouse | |
靶点/蛋白质: | 特异性: | Human | |
存储温度: | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | 存储溶液: | |
应用: | E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 | 参考文献: | 1. Cell. 2009 Jul 23;138(2):389-403. 2. Biochem Biophys Res Commun. 2009 Apr 10;381(3):443-7. |
详情介绍: | Function Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Cellular_Location Nucleus. Note=Mainly nuclear Tissue_Location Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes | ||
别名: | NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, NEDD-8, Ubiquitin-like protein Nedd8, NEDD8 | 说明书: |