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NDUFA1 Antibody (monoclonal) (M01)
  • 商城价格 登录后可查看价格
  • 货号 LM17404
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 100 μg
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM17404

规格：

100 μg

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the hydrophobic protein (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

来源：

mouse

靶点/蛋白质：

NDUFA1 (AAH00266, 24 a.a. ~ 70 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

特异性：

Human

存储温度：

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

存储溶液：

Clear, colorless solution in phosphate buffered saline, pH 7.2.

应用：

WB~~1:500~1000

参考文献：

Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts. Mor?n M, et al. Biochim Biophys Acta, 2010 May. PMID 20153825.Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Potluri P, et al. Mol Genet Metab, 2009 Apr. PMID 19185523.X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy. Fernandez-Moreira D, et al. Ann Neurol, 2007 Jan. PMID 17262856.Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits. Vogel RO, et al. J Biol Chem, 2007 Mar 9. PMID 17209039.

详情介绍：

别名：

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1, Complex I-MWFE, CI-MWFE, NADH-ubiquinone oxidoreductase MWFE subunit, NDUFA1

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