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品牌: | Leading Biology | 货号: | LM16488 |
规格: | 500 μg | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 来源: | Mouse |
靶点/蛋白质: | Recognizes Apolipoprotein A-I (Apo A-I). This product does not cross-react with APO A-II or APO B in competitive RIA. | 特异性: | Human |
存储温度: | 存储溶液: | ||
应用: | IHC-P (10 μg/ml), | 参考文献: | Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983). Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983). Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983). Seilhamer J.J.,et al.DNA 3:309-317(1984). Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984). |
详情介绍: | Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Cellular_Location Secreted. Tissue_Location Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. | ||
别名: | APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI | 说明书: |