搜索

购物车()
胎牛血清 移液枪头 PEI DMEM eppendorf
首页> 生物试剂> 免疫检测> 抗体


CD33 / SIGLEC3 (Myeloid Cell Surface Antigen) Antibody - Purified Ab Conjugated to PE
  • 商城价格 登录后可查看价格
  • 货号 LM10318
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 0.5 ml
  • 单位 个
  • 储存条件 见详情介绍
  • 现货状态
  • 数量

    - +

    成功收藏产品
  • 立即购买
登录后可见商家信息
热门推荐
商家描述 产品评价(0)

品牌：

Leading Biology

货号：

LM10318

规格：

0.5 ml

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

来源：

Mouse

靶点/蛋白质：

特异性：

Human

存储温度：

Store at 2 to 8°C.Antibody is stable for 24 months.

存储溶液：

Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

应用：

参考文献：

Favaloro EJ, Bradstock KF, Kabral A, Grimsley P, Berndt MC: Characterization of monoclonal antibodies to the human myeloid-differentiation antigen, 'gp67' (CD-33). Dis Markers. 1987;5(4):215-25. | Favaloro EJ, Bradstock KF, Kabral A, Grimsley P, Zowtyj H, Zola H: Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging to CD-11b, CD-13 and CD-33. Br J Haematol. 1988;69(2):163-71

详情介绍：

Function Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Cellular_Location Cell membrane; Single-pass type I membrane protein Tissue_Location Monocytic/myeloid lineage cells.

别名：

Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD33, CD33, SIGLEC3

说明书：

返回顶部