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CD20 / MS4A1 (B-Cell Marker) Antibody - Purified Ab Conjugated to PE
  • 商城价格 登录后可查看价格
  • 货号 LM10247
  • 品牌 Leading Biology ( 经销商 )
  • CAS号 见包装
  • 规格/包装 0.5 ml
  • 单位 个
  • 储存条件 见详情介绍
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品牌：

Leading Biology

货号：

LM10247

规格：

0.5 ml

产品官网链接：

产品分类：

单克隆抗体

研究领域：

产品概述：

Recognizes a protein of 33-37kDa, identified as CD20 (Workshop V; Code CD20.12). B9E9 recognizes extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, B cell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in B-cell activation and cell cycle progression.

来源：

Mouse

靶点/蛋白质：

特异性：

Human

存储温度：

Store at 2 to 8°C.Antibody is stable for 24 months.

存储溶液：

Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

应用：

参考文献：

Schlossman S, et al. (eds). Leukocyte Typing V, Oxford University Press, Oxford, p511-515, 1995. | Tedder TF and Schlossman SF. Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. J Biol Chem 1988, 263(20):10009-10015.Bubien JK et al. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol 1993, 121(5):1121-1132.Tedder TF and Engel P. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today 1994, 15(9):450-454. | Kanzaki M et al. Expression of calcium-permeable cation channel CD20 accelerates progression through the G1 phase in Balb/c 3T3 cells. J Biol Chem 1995, 270(22):13099-13104

详情介绍：

Function This protein may be involved in the regulation of B-cell activation and proliferation. Cellular_Location Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor Tissue_Location Expressed on B-cells.

别名：

B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20

说明书：

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