产品名：重组人GDF-15

产品号：LT-0092

产品信息：

GDF-15属于TGF-β细胞因子家族,其成员在产前发育和产后生长中发挥重要作用,重塑和维持各种组织和器官。GDF-15主要表达在胎盘中，在其他组织上表达较少。GDF-15存在于羊水中、在孕妇的血清中含量升高表明GDF-15参与妊娠和胚胎发育。GDF-15通常具有肿瘤抑制作用，是激活p53信号通道反应中产生和分泌的主要因子之一。有趣的是,GDF-15的血清水平与几种肿瘤的形成呈正相关,包括某些结肠癌、胰腺癌、前列腺癌。

别名：

Growth/Differentiation Factor-15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor

英文信息：

GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Human GDF-15/MIC-1 is 24.6 kDa.

氨基酸序列:

ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI

表达宿主来源:

E.coli

保存条件：

4℃保存6个月，-20℃保存一年或者-80℃长期保存。

纯度&内毒素: 

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level <0.5EU/ug