产品名：重组人白介素1α（IL-1α）

产品号：LT-0110

产品信息：

IL-1α可以介导外周血淋巴细胞表面上调表达IL-2R。当IL-1α与IFN γ（Cat.No：LT0106）和激活性CD3单抗（Cat.No: LTA002）合用时，可以明显提高CIK

细胞的毒作用。

IL-1α可体外刺激CD4⁺T细胞的增殖，诱导IL-2的产生，共刺激CD8⁺/IL 1R⁺ T细胞活化，并刺激成熟的B细胞增殖和免疫球蛋白的分泌。

别名：

Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

英文描述：

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

表达宿主来源:

E.coli

保存条件：

4℃保存6个月，-20℃保存一年或者-80℃长期保存。

纯度&内毒素:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level <0.5EU/ug

The purity of rhIL-1α was determined by SDS-PAGE of reduced rhIL-1α and staining overnight with Coomassie Blue.